Interferon-α down-regulates the interleukin-6 receptor in a human multiple myeloma cell line, U266
نویسندگان
چکیده
منابع مشابه
Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266.
It has been reported recently that freshly isolated human myeloma cell cultures proliferate in response to added interleukin-6 (IL-6). Endogenous levels of IL-6 found in the same cultures suggested that an autocrine growth loop may contribute to cell growth. However, the lack of homogenous cell populations in primary myeloma cultures has made it difficult to distinguish between paracrine and au...
متن کاملDifferential human multiple myeloma cell line responsiveness to interferon-alpha. Analysis of transcription factor activation and interleukin 6 receptor expression.
Although IFN-alpha is commonly used as maintenance treatment for multiple myeloma patients, its effectiveness is varied. In this study, we have used a panel of IL-6 responsive myeloma cell lines that vary remarkably in responsiveness to IFN-alpha. Three cell lines were growth arrested by IFN-alpha; however, IFN-alpha significantly stimulated growth of the fourth cell line, KAS-6/1. Our studies ...
متن کاملInterleukin 6 differentially potentiates the antitumor effects of taxol and vinblastine in U266 human myeloma cells.
Newer therapeutic strategies for the treatment of multiple myeloma have focused on antagonizing the growth-promoting functions of interleukin 6 (IL-6). In this study, we examined the antitumor effects of two mechanistically different microtubule poisons, Taxol and vinblastine, in U266 human myeloma cells and determined whether IL-6 altered these effects. Taxol and vinblastine led to a dose-depe...
متن کاملgamma-Interferon in multiple myeloma: inhibition of interleukin-6 (IL-6)-dependent myeloma cell growth and downregulation of IL-6-receptor expression in vitro.
In multiple myeloma, malignant plasma cells from most patients with active disease proliferate spontaneously when cultured for 5 days in vitro. This spontaneous proliferation is related to the endogenous production of interleukin-6 (IL-6), the major myeloma-cell growth factor. A 50% inhibitory dose (100 U/mL) of human recombinant gamma-interferon (hr gamma-IFN) blocked the proliferation of myel...
متن کامل?-Interferon in Multiple Myeloma: Inhibition of Interleukin-6 (IL-6)- Dependent Myeloma Cell Growth and Downregulation of IL-6-Receptor Expression In Vitro
In multiple myeloma, malignant plasma cellsfrom most patients with active disease proliferate spontaneously when cultured for 5 days in vitro. This spontaneous proliferation is related to the endogenous production of interleukin-6 (IL6), the major myeloma-cell growth factor. A 50% inhibitory dose ( I 0 0 U/mL) of human recombinant 7-interferon (hry IFN) blocked the proliferation of myeloma cell...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1995
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3090175